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- W2349660060 abstract "Objective To evaluate the expression of BCSGl,c-erbB-2,VEGF in human breast carcinoma and the relationship with clinical-pathological features.Methods By immunohistochemical S-P method,the expressions of BCSG1,cerbB-2 and VEGF were examined in 316 breast cancer specimens,the correlation between these indexes and clinical-pathologi cal features were analyzed.Results BCSG1 and VEGF positive rate were 67.1%and 61.0%.The expression of BCSG1 and VEGF were both positively correlated with histological grade,lymph node metastasis and clinical stage(r=0.152,r= 0.510,r =0.460 andr =0.166,r =0.142,r =0.142,P 0.05,P 0.01),and both independence with ER,PR, tumor size,menstruation,pathology type(P0.05).C-erbB-2 positive rate was 32.2%,the expression of c-erbB-2 was positively correlated with tumor size,histological grade,lymph node metastasis and clinical stages(r =0.173,r =0.157, r=0.365,r=0.306,P0.01),but negatively correlated with ER,PR expressions(r=-0.149,r=-0.154,P 0.05),and independence with menstruation and pathology type(P0.05).The co-expression of these three proteins positively correlated with lymph node metastasis,clinical stages and histological grade,(r=0.457,r=0.377,r=0.228,P 0.05).The expression of BCSG1,c-erbB-2 and VEGF were all positively correlated with each other(P0.01).Conclusion The expression of BCSG1,c erbB 2 and VEGF were correlated with carcinogenesis of breast cancer nd development.The high co-expression of the three proteins predicts strong aggression and metastasis ability." @default.
- W2349660060 created "2016-06-24" @default.
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- W2349660060 date "2012-01-01" @default.
- W2349660060 modified "2023-09-25" @default.
- W2349660060 title "Expressions of BCSG1,c-erbB-2 and VEGF in breast cancer and correlation with clinical-pathological features" @default.
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