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- W2349668511 abstract "[Objective] To investigate the effect of resveratrol on sodium nitroprusside-induced chondrocyte apoptosis and apoptosis regulatory genes bax and bcl-2 expression.[Methods]After routinely culturing of articular chondrocyte,different concentrations of resveratrol(25 μmol/L 、50 μmol/L、100 μmol/L)were applied and sodium nitroprusside(SNP)(2.5 mmol / L) were ased to induce apoptosis.MTT assay was used to detect the activity of chondrocytes,DAPI staining and flow cytometry of apoptosis in each group.Sirt1,bax,bcl-2 expression were detected using western-blot in each group.The cell Sirt1 mRNA expression was detected using RT-PCR method.[Results]MTT assay showed increasing cell activity with increasing resveratrol concentration after treatment.DAPI staining,flow cytometry analysis showed relatively few cell apoptosis after treatment.Western-blot analysis showed that,sirt1,bcl-2 of treated cells increased in turn and the bax decreased with the increase of the concentration of resveratrol.RT-PCR assay showed that sirt1 mRNA expression of resveratrol-treated cells increased gradually with the increase of concentration.[Conclusion]Resveratrol activated sirt1,so that the bcl-2 / bax expression increased.This is one of the mechanisms that resveratrol inhibit chondrocyte apoptosis and prevent osteoarthritis." @default.
- W2349668511 created "2016-06-24" @default.
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- W2349668511 date "2012-01-01" @default.
- W2349668511 modified "2023-09-23" @default.
- W2349668511 title "Effects of resveratrol on the expression of the bax and bcl-2 in SNP-induced chondrocyte apoptosis" @default.
- W2349668511 hasPublicationYear "2012" @default.
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