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- W2349668883 abstract "OBJECTIVE: To summerize the stromal fibroblasts and study on present situation of the development of cancer,to study on stromal fibroblasts,growth and metastasis of cancer and its influence on treatment.METHODS: Application of Medline,PubMed and CNKI periodical full-text database retrieval system were searched with breast cancer,stromal,carcinoma-associated fibroblasts cells and tumor micro-environments as keywords,from 1994 to 2011,and 258 English literature and 56 chinese literature were got.Inclusion criteria: 1.morphology and characteristics of cancer stromal fibroblasts.2.the method of isolation and culture.3.the functions.4.tumorigenesis,growth and metastasis of cancer,and the impact of treatment.RESULTS: Breast cancer stromal fibroblasts by mutual contact between cells in a variety of chemokines and/or the action of cytokines via different signaling pathways promoted malignant transformation of epithelial cells and in cancer occurrence,and play an important role in the growth and metastasis.The specific mechanism is not clear yet.CONCLUSIONS: Breast cancer stromal fibroblasts can promote the development of cancer.Endocrine therapy and chemotherapy for cancer has important implications and it may be new target for cancer treatment." @default.
- W2349668883 created "2016-06-24" @default.
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- W2349668883 date "2012-01-01" @default.
- W2349668883 modified "2023-09-28" @default.
- W2349668883 title "Status and outlook of research on stromal fibroblasts in breast cancer in vivo and in vitro" @default.
- W2349668883 hasPublicationYear "2012" @default.
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