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- W234967861 startingPage "80" @default.
- W234967861 abstract "Hypertension is a major risk factor of cardiovascular diseases and a most important health problem in developed countries. Investigations on pathophysiology of hypertension have been based on gene products from coding region that occupies only about 1% of total genome region. On the other hand, non-coding region that occupies almost 99% of human genome has been regarded as “junk” for a long time and went unnoticed until these days. But recently, it turned out that noncoding region is extensively transcribed to non-coding RNAs and has various functions. This review highlights recent updates on the significance of non-coding RNAs such as micro RNAs and long non-coding RNAs (lncRNAs) on the pathogenesis of hypertension, also providing an introduction to basic biology of noncoding RNAs. For example, microRNAs are associated with hypertension via neuro-fumoral factor, sympathetic nerve activity, ion transporters in kidneys, endothelial function, vascular smooth muscle phenotype transformation, or communication between cells. Although reports of lncRNAs on pathogenesis of hypertension are scarce at the moment, new lncRNAs in relation to hypertension are being discovered at a rapid pace owing to novel techniques such as microarray or next-generation sequencing. In the clinical settings, clinical use of non-coding RNAs in identifying cardiovascular risks or developing novel tools for treating hypertension such as molecular decoy or mimicks is promising, although improvement in chemical modification or drug delivery system is necessary. Keywords: Biomarker, cardiovascular disease, hypertension, lncRNA, long non-coding RNA, microRNA, miRNA, therapy." @default.
- W234967861 created "2016-06-24" @default.
- W234967861 creator A5051420763 @default.
- W234967861 date "2015-07-31" @default.
- W234967861 modified "2023-10-16" @default.
- W234967861 title "Non-coding RNAs and Hypertension–Unveiling Unexpected Mechanisms of Hypertension by the Dark Matter of the Genome" @default.
- W234967861 cites W1964915623 @default.
- W234967861 cites W1965235907 @default.
- W234967861 cites W1966309110 @default.
- W234967861 cites W1971726501 @default.
- W234967861 cites W1973988603 @default.
- W234967861 cites W1974795385 @default.
- W234967861 cites W1975538620 @default.
- W234967861 cites W1975847255 @default.
- W234967861 cites W1977670851 @default.
- W234967861 cites W1977943782 @default.
- W234967861 cites W1978721398 @default.
- W234967861 cites W1985396932 @default.
- W234967861 cites W1986673875 @default.
- W234967861 cites W1986915486 @default.
- W234967861 cites W1987722841 @default.
- W234967861 cites W1988791583 @default.
- W234967861 cites W1990656514 @default.
- W234967861 cites W1991102782 @default.
- W234967861 cites W1994494031 @default.
- W234967861 cites W2001291401 @default.
- W234967861 cites W2002164502 @default.
- W234967861 cites W2003171726 @default.
- W234967861 cites W2006905341 @default.
- W234967861 cites W2007203150 @default.
- W234967861 cites W2007755299 @default.
- W234967861 cites W2010012954 @default.
- W234967861 cites W2010691531 @default.
- W234967861 cites W2011868427 @default.
- W234967861 cites W2014346055 @default.
- W234967861 cites W2015052875 @default.
- W234967861 cites W2015285679 @default.
- W234967861 cites W2018352906 @default.
- W234967861 cites W2018804632 @default.
- W234967861 cites W2019888096 @default.
- W234967861 cites W2020678193 @default.
- W234967861 cites W2021723069 @default.
- W234967861 cites W2027984042 @default.
- W234967861 cites W2029226202 @default.
- W234967861 cites W2031529022 @default.
- W234967861 cites W2032894309 @default.
- W234967861 cites W2033196219 @default.
- W234967861 cites W2035210226 @default.
- W234967861 cites W2037475514 @default.
- W234967861 cites W2038922427 @default.
- W234967861 cites W2039347167 @default.
- W234967861 cites W2039816251 @default.
- W234967861 cites W2042277549 @default.
- W234967861 cites W2043324403 @default.
- W234967861 cites W2045586901 @default.
- W234967861 cites W2046012789 @default.
- W234967861 cites W2046291314 @default.
- W234967861 cites W2050245631 @default.
- W234967861 cites W2051032563 @default.
- W234967861 cites W2053687622 @default.
- W234967861 cites W2054824372 @default.
- W234967861 cites W2054836245 @default.
- W234967861 cites W2056106092 @default.
- W234967861 cites W2060434878 @default.
- W234967861 cites W2062502437 @default.
- W234967861 cites W2062930407 @default.
- W234967861 cites W2064933761 @default.
- W234967861 cites W2067609507 @default.
- W234967861 cites W2070777085 @default.
- W234967861 cites W2071271349 @default.
- W234967861 cites W2071527303 @default.
- W234967861 cites W2072096683 @default.
- W234967861 cites W2072385683 @default.
- W234967861 cites W2072443346 @default.
- W234967861 cites W2073697032 @default.
- W234967861 cites W2081236497 @default.
- W234967861 cites W2082438956 @default.
- W234967861 cites W2087377443 @default.
- W234967861 cites W2088422918 @default.
- W234967861 cites W2090504182 @default.
- W234967861 cites W2091445250 @default.
- W234967861 cites W2093478617 @default.
- W234967861 cites W2101064855 @default.
- W234967861 cites W2101567720 @default.
- W234967861 cites W2101839496 @default.
- W234967861 cites W2105011888 @default.
- W234967861 cites W2106052194 @default.
- W234967861 cites W2106077567 @default.
- W234967861 cites W2109313316 @default.
- W234967861 cites W2111778724 @default.
- W234967861 cites W2116236561 @default.
- W234967861 cites W2117100078 @default.
- W234967861 cites W2117307038 @default.
- W234967861 cites W2118947150 @default.
- W234967861 cites W2120939324 @default.
- W234967861 cites W2121352589 @default.
- W234967861 cites W2121972108 @default.
- W234967861 cites W2129237728 @default.