Matches in SemOpenAlex for { <https://semopenalex.org/work/W2349696134> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2349696134 startingPage "624" @default.
- W2349696134 abstract "PURPOSE To study the effect of simvastatin on osteoblast proliferation, differentiation and mineralization and to explore the mechanism of stimulation of bone formation by simvastatin. METHODS Six 8-hour healthy SD rats were used for the experiment. In order to harvest vital osteoblast, this research modified the traditional tissue piece method to culture primary osteoblast of rat calvarias.The effect of simvastatin in different concentration(1.0micromol/L,0.5micromol/L,0.25micromol/L,0.125micromol/L) on osteoblast was measured using MTT to assay osteoblasts proliferation, alkaline phosphatase activity of osteoblasts was measured, the level of osteocalcin (OC) was detected, the capacity of mineralization was investigated by counting the mean mineralization area with Image-Pro Plus 6.0.The data was analyzed with SPSS 13.0 software package for one-way ANOVA. RESULTS Compared with the control group, the osteoblasts proliferation was inhibited in the experimental groups in a dose-dependent manner. It showed that the alkaline phosphatase activity of osteoblast was increased in all experimental groups. The level of OC of osteoblasts showed a significant increase in all treatment groups. With regard to osteoblast capability of mineralization, the mineralization area was also increased, compared with the control group (P<0.05). CONCLUSION Simvastatin inhabits the proliferation of osteoblasts in vitro, but promotes differentiation and mineralization of osteoblast." @default.
- W2349696134 created "2016-06-24" @default.
- W2349696134 creator A5001004716 @default.
- W2349696134 creator A5053823828 @default.
- W2349696134 creator A5074683200 @default.
- W2349696134 creator A5083729859 @default.
- W2349696134 date "2009-12-01" @default.
- W2349696134 modified "2023-09-25" @default.
- W2349696134 title "The effect of simvastatin on osteoblastic bionomics of rats" @default.
- W2349696134 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20143026" @default.
- W2349696134 hasPublicationYear "2009" @default.
- W2349696134 type Work @default.
- W2349696134 sameAs 2349696134 @default.
- W2349696134 citedByCount "0" @default.
- W2349696134 crossrefType "journal-article" @default.
- W2349696134 hasAuthorship W2349696134A5001004716 @default.
- W2349696134 hasAuthorship W2349696134A5053823828 @default.
- W2349696134 hasAuthorship W2349696134A5074683200 @default.
- W2349696134 hasAuthorship W2349696134A5083729859 @default.
- W2349696134 hasConcept C111696902 @default.
- W2349696134 hasConcept C126322002 @default.
- W2349696134 hasConcept C131075544 @default.
- W2349696134 hasConcept C134018914 @default.
- W2349696134 hasConcept C160160445 @default.
- W2349696134 hasConcept C178790620 @default.
- W2349696134 hasConcept C181199279 @default.
- W2349696134 hasConcept C185592680 @default.
- W2349696134 hasConcept C202751555 @default.
- W2349696134 hasConcept C2776329913 @default.
- W2349696134 hasConcept C2778260815 @default.
- W2349696134 hasConcept C2780783641 @default.
- W2349696134 hasConcept C537208039 @default.
- W2349696134 hasConcept C55493867 @default.
- W2349696134 hasConcept C71924100 @default.
- W2349696134 hasConcept C86803240 @default.
- W2349696134 hasConceptScore W2349696134C111696902 @default.
- W2349696134 hasConceptScore W2349696134C126322002 @default.
- W2349696134 hasConceptScore W2349696134C131075544 @default.
- W2349696134 hasConceptScore W2349696134C134018914 @default.
- W2349696134 hasConceptScore W2349696134C160160445 @default.
- W2349696134 hasConceptScore W2349696134C178790620 @default.
- W2349696134 hasConceptScore W2349696134C181199279 @default.
- W2349696134 hasConceptScore W2349696134C185592680 @default.
- W2349696134 hasConceptScore W2349696134C202751555 @default.
- W2349696134 hasConceptScore W2349696134C2776329913 @default.
- W2349696134 hasConceptScore W2349696134C2778260815 @default.
- W2349696134 hasConceptScore W2349696134C2780783641 @default.
- W2349696134 hasConceptScore W2349696134C537208039 @default.
- W2349696134 hasConceptScore W2349696134C55493867 @default.
- W2349696134 hasConceptScore W2349696134C71924100 @default.
- W2349696134 hasConceptScore W2349696134C86803240 @default.
- W2349696134 hasIssue "6" @default.
- W2349696134 hasLocation W23496961341 @default.
- W2349696134 hasLocation W23496961342 @default.
- W2349696134 hasOpenAccess W2349696134 @default.
- W2349696134 hasPrimaryLocation W23496961341 @default.
- W2349696134 hasRelatedWork W162993444 @default.
- W2349696134 hasRelatedWork W2351634879 @default.
- W2349696134 hasRelatedWork W2357488441 @default.
- W2349696134 hasRelatedWork W2357575115 @default.
- W2349696134 hasRelatedWork W2360519037 @default.
- W2349696134 hasRelatedWork W2365362859 @default.
- W2349696134 hasRelatedWork W2367155867 @default.
- W2349696134 hasRelatedWork W2367383372 @default.
- W2349696134 hasRelatedWork W2368929102 @default.
- W2349696134 hasRelatedWork W2370648588 @default.
- W2349696134 hasRelatedWork W2381932454 @default.
- W2349696134 hasRelatedWork W2382839224 @default.
- W2349696134 hasRelatedWork W2384643506 @default.
- W2349696134 hasRelatedWork W2388646334 @default.
- W2349696134 hasRelatedWork W2388760440 @default.
- W2349696134 hasRelatedWork W2392698632 @default.
- W2349696134 hasRelatedWork W2418601485 @default.
- W2349696134 hasRelatedWork W2444051944 @default.
- W2349696134 hasRelatedWork W2990098276 @default.
- W2349696134 hasRelatedWork W3028962348 @default.
- W2349696134 hasVolume "18" @default.
- W2349696134 isParatext "false" @default.
- W2349696134 isRetracted "false" @default.
- W2349696134 magId "2349696134" @default.
- W2349696134 workType "article" @default.