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- W2349700145 abstract "Objective To explore the relationship between serum IP 10 levels and the disease activity, and the role of IP 10 in the pathogenesis of SLE Methods Sera were Collected from 112 patients with SLE, 40 healthy volunteers and 30 patients with RA Serum IP 10 levels were measured by ELISA Results IP 10 levels in active groups(508 7±252 4)μg/L were markedly higher than those in inactive groups(322 2±95 9)μg/L and controls(124 9±41 3)μg/L( P 0 001) The levels of IP 10 in the active lupus nephritis(550 9±206 1)μg/L were significantly higher than in active no renal involvement group (354 8±105 3)μg/L and controls( P 0 001) Furthermore, Serum IP 10 levels showed much higher in WHO classes Ⅲ and Ⅳ (629 85±164)μg/L than those in WHO classes Ⅱ and Ⅴ(302 9±207 1)μg/L ( P 0 01) In addition, serum IP 10 levels were markedly increased in the SLE patients depending on the disease activity, the levels of IP 10 correlated significantly with the overall SLEDAI score ( r = 0 631 2, P 0 001), as well as the renal SLEDAI score( r = 0 688 0, P 0 001) Conclusion IP 10 may play an important role in the pathogenesis of SLE, especially in the patients with lupus nephritis Serum IP 10 levels correlated significantly with the activity of SLE It suggested that serum IP 10 level could be a good indicator in SLE with renal involvement" @default.
- W2349700145 created "2016-06-24" @default.
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- W2349700145 date "2005-01-01" @default.
- W2349700145 modified "2023-09-26" @default.
- W2349700145 title "Serum levels of IFN-Inducible protein-10 relating to the activity of systemic lupus erythematosus" @default.
- W2349700145 hasPublicationYear "2005" @default.
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