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- W2349735270 abstract "Objective:To investigate the relationships between gene polymorphism and the maternal risks for Down syndrome in Chinese Han women from Zhejiang province.Methods: A case-control study was conducted.The polymorphism of C677T,A1298C in methylenetetrahydrofolate reductase(MTHFR) and A2756G in methionine synthase(MTR) were analysed in 84 mothers of children with DS(the cases)and 120 matched mothers(the controls) by Polymerase Chain Reaction(PCR) and DNA sequencing.Results: There were no significant differences for the frequencies of MTHFR 677 T and CTTT,MTHFR 1298 C,AC,CC and MTR 2756 G,AA,AG between two groups(P0.05).Also there were no significant differences with combined frequency of three loci genotype between two groups(OR =0.692,P0.05).Conclusion: MTHFR C677T,MTHFR A1298C,MTR A2756G and the combined frequencies were not the risks factors of DS in southern zhejiang China women." @default.
- W2349735270 created "2016-06-24" @default.
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- W2349735270 date "2012-01-01" @default.
- W2349735270 modified "2023-09-25" @default.
- W2349735270 title "Genetic polymorphisms involved in folate metabolism as maternal risk factors for Down syndrome" @default.
- W2349735270 hasPublicationYear "2012" @default.
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