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- W2349744530 abstract "Objective:To study the expression of interleukin-17(IL-17) and receptor activator of nuclear factor kappa B ligand(RANKL) in synovium of CIA rat and the effects of 99Tc-TDP on IL-17 and RANKL.Methods:The rats were induced by injecting typeⅡcollagen and complete Freud's adjuvant.The rats successfully induced CIA(n=20) were divided into two groups at random: the model group(n=10) and the 99Tc-TDP group(n=10),in addition,the normal control group(n=10) was set.Arthritis was evaluated by arthritis index(AI).The concentration of IL-17 and RANKL in serum and synovial fluid was measured,Synovial Pathological Score was observed by microscope,and the expression of IL-17 and RANKL in synovium was detected by immunohistochemistry.Results: The concentration of IL-17 in serum and synovial fluid,RANKL in synovial fluid,Synovial Pathological Score,and the expression of IL-17 and RANKL in synovium were increased in model and 99Tc-TDP group compared with normal control group(P0.05).99Tc-TDP treatment prevented the increase of all above indexes(P0.05).The concentration of RANKL in serum was on significant difference between each of groups(P0.05). Conclusion: IL-17 and RANKL play a role in joint synovitis of CIA rat.99Tc-TDP may relieve synovium lesions in mechanisms by inhibiting the expression of IL-17 and RANKL in synovium." @default.
- W2349744530 created "2016-06-24" @default.
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- W2349744530 date "2010-01-01" @default.
- W2349744530 modified "2023-09-28" @default.
- W2349744530 title "Expression of IL-17 and RANKL in synovium of CIA rat and the interventional effect of ~(99)Tc-TDP" @default.
- W2349744530 hasPublicationYear "2010" @default.
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