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- W2349762556 abstract "Objective To investigate effects on L-type calcium currents(ICa-L)and cytosolic Ca2+ concentrations of rat ventricular myocytes by different isomers of amlodipine(Aml).Methods Ventricular myocytes were isolated by enzyme digestion.ICa-L and channel kinetic parameters with S-Aml,R-Aml and R,S-Aml at concentrations of 0.1,0.5,1,5 and 10 μmol/L were recorded respectively by whole-cell patch clamp configuration.Cytosolic Ca2+ concentrations were measured by fluorescent probe Fura-2/AM.Effects on cytosolic Ca2+ concentrations with S-Aml,R-Aml and R,S-Aml at 1,5,10,50 and 100 μmol/L were compared respectively.Results ICa-L and peak currents were gradually blocked,I-V curves were shifted upward,steady activation and inactivation curves were shifted to the left,and recovery time from inactivation was prolonged with the increase of S-Aml and R,S-Aml concentrations from 0.1 μmol/L to 10 μmol/L(P0.05).Cytosolic Ca2+ concentrations were gradually reduced from 1 to 100 μmol/L,and half inhibition concentrations of S-Aml and R,S-Aml were 8.13 μmol/L and 16.19 μmol/L(P0.05).However,R-Aml at different concentrations had no effects on ICa-L,channel kinetics parameters and cytosolic Ca2+ concentrations(P0.05).Conclusion S-Aml and R,S-Aml have blockade effects on L-type calcium current,while R-Aml has no pharmacological actions associated with L-type calcium current." @default.
- W2349762556 created "2016-06-24" @default.
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- W2349762556 date "2008-01-01" @default.
- W2349762556 modified "2023-09-23" @default.
- W2349762556 title "Effects on L-type calcium current and cytosolic Ca~(2+) concentration of rat ventricular myocytes by different isomers of amlodipine" @default.
- W2349762556 hasPublicationYear "2008" @default.
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