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- W2349767632 abstract "Objective To investigate the pathological relationship between pyruvate kinase(PK) level and hypertriglyceridemia complicated by the metabolism disorder of uric acid(UA) and glucose(GLU).Methods On the base of copied hypertriglyceridemia model by high fructose diet,the model of hypertriglyceridemia complicated by hyperuricemia and hyperglycemia was established.The changes of serum levels of triglyceride(TG),UA and GLU in model rats were detected dynamically.The experiments were stopped respectively when only TG level markedly increased(on 21st day) and TG,UA and GLU levels increased synchronously(on 57th day).The activity of PK in the serum and liver were detected by spectrophotometry and PK protein expression in the liver was detected by immunohistochemistry assay after killing rats.Results The serum TG level was increased obviously in the model group than that in the normal control group,and UA and GLU levels were not changed 21 days after model establishment.The levels of TG,UA and GLU were obviously increased in the model group than those in the normal control group 29 days after model establishment,and kept higher levels till to 57th day.The PK activity and protein expression in the serum or liver in the model group were obviously decreased.Conclusion The decrease of PK activity may be one of the causes of hypertriglyceridemia and its complications in rats." @default.
- W2349767632 created "2016-06-24" @default.
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- W2349767632 date "2008-01-01" @default.
- W2349767632 modified "2023-09-28" @default.
- W2349767632 title "Active changes and protein expression of pyruvate kinase in condition of hypertriglyceridemia complicated by hyperuricemia and hyperglycemia" @default.
- W2349767632 hasPublicationYear "2008" @default.
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