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- W2349774563 abstract "OBJECTIVE:To investigate the effect of intensive simvastatin treatment and conventional treatment for inflammation and oxidative stress in patients with acute coronary syndrome.METHODS:64 patients with acute coronary syndrome were randomly divided into 2 groups,and conventional treatment group was given conventional dose of simvastatin 20 mg and intensive treatment group was given intensive treatment of simvastatin 40 mg,and healthy control group without any interventions.The CRP,MDA,SOD and GSH-Px were determined before and after treatment.RESULTS:The levels of MDA and SOD,GSH-Px activity were significant different between intensive treatment group and conventional treatment group(P0.05),when the patients were discharged.But the difference of CRP levels was found in two groups after 4 weeks(P0.05).After 8 weeks,the difference between 2 groups exited between 2 groups(P0.05).After 12 weeks,the difference between 2 groups had no statistical difference(P0.05).CONCLUSION:Intensive simvastatin treatment can protect patients with acute coronary syndrome patients from inflammation and oxidative stress,compared with conventional treatment." @default.
- W2349774563 created "2016-06-24" @default.
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- W2349774563 date "2012-01-01" @default.
- W2349774563 modified "2023-09-27" @default.
- W2349774563 title "Effects of Intensive Simvastatin Treatment on Inflammation and Oxidative Stress in Patients with Acute Conoary Syndrome" @default.
- W2349774563 hasPublicationYear "2012" @default.
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