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- W2349794901 abstract "Objective:To investigate the association of single nucleotide polymorphism in mdr1C3435T with susceptibility to ovarian cancer.Methods:mdr1C3435T gene was determined by PCR-RFLP method in 135 ovarian cancer patients(cases group) and 146 healthy women(control group).Results:The frequency of C/C genotype in cases group(30.37%) was significantly lower than that in controls(47.95%),and the frequencies of T/C(44.44%)and T/T(25.19%) respectively in cases group were significantly higher than those in controls(T/C38.35%,T/T13.7%).The frequency of mdr1C3435T null genotype in cases group(25.19%) was higher than that in control group(13.7%).Compared with controls,the susceptibility of ovarian cancer with the T/T genotype was increased by 2.121-fold.There was significant difference in frequency of mdr1C3435T null and nonnull genotype between cases and controls of average age(P 0.05).In more than 50 year age group,the frequency of mdr1C3435T null genotype in cases(20.41%)was higher than that in controls(5.1%).Compared with controls,the susceptibility to ovarian cancer with the T/T genotype was increased by 2.533-fold.Conclusion:mdr1C3435T gene mutation genotype could increase risk of ovarian cancer.mdr1C3435T polymorphism is an important risk factor for susceptibility to ovarian cancer.Age increases the risk of ovarian cancer.In women older than 50 years,T/T genotype increases the risk of ovarian cancer." @default.
- W2349794901 created "2016-06-24" @default.
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- W2349794901 date "2009-01-01" @default.
- W2349794901 modified "2023-09-24" @default.
- W2349794901 title "Association of single nucleotide polymorphism in mdr1C3435T with susceptibility to ovarian cancer" @default.
- W2349794901 hasPublicationYear "2009" @default.
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