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- W2349812801 abstract "AIM To compare the effects of sufentanil and fentanyl on cerebral injury in patients undergoing coronary artery bypass graft during cardiopulmonary bypass(CPB).METHODS Thirty patients scheduled for coronary artery bypass graft(ASAⅡ-Ⅲ,n = 30) were randomly divided into 2 groups(15 for each).Anesthesia was induced with sufentanil(1.0 - 1.5μg·kg~(-1) and maintained with 1.0 - 2.0μg·kg~(-1)·h~(-1) or fentanyl(10 - 15μg·kg~(-1) and maintained with 10 - 20μg·kg~(-1)·h~(-1)),the other drugs were same in both groups.Blood samples were taken from jugular vein for the determination of plasma S-100βprotein and neurone specific enolase(NSE) concentration before skin incision(T_0),at 30 min after CPB(T_1),the end of CPB (T_2),4 h(T_3),12 h(T_4) and 24 h(T_5) after the operation.The mean mini-mental state examination (MMSE) scores were calculated before anesthesia,1 d and 3 d after the operation.RESULTS The plasma concentration of S-100βprotein and NSE were significantly increased after CPB in both groups as compared with T_0(P0.05).The levels of S-100βprotein at T_1-T_3,NSE at T_1-T_4 were lower in the sufentanil group than those in the fentanyl group(P0.05).The MMSE scores at 1 d after operation were higher in the sufentanil group as compared with the fentanyl group.There were no serious adverse reactions observed in both groups. CONCLUSION Compared with fentanyl,sufentanil can decrease the releasing of S-100βprotein and NSE,and appears to provide better brain protection to patients undergoing coronary artery bypass graft during CPB." @default.
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- W2349812801 date "2010-01-01" @default.
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- W2349812801 title "Effects of sufentanil vs.fentanyl on cerebral injury in patients undergoing coronary artery bypass graft" @default.
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