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- W2349814274 abstract "Objective To observe the clinical effects of Bushen Gujing Decoction plus high-dose Astragalus injection on immunological condition in patients with lupus nephritis(LN) of spleen-kidney yang-deficiency.Methods Thirty LN patients were randomly divided into treatment group(n=15) and control group(n=15);steroids and cyclophosphamide(CTX) were administered to all patients,while Bushen Gujing Decoction plus Astragalus injection were only administered to patients in the treatment group.After 3-month treatment,24h urine protein,SLE disease activity index score(SLEDAI score),T lymphocytes subsets,CD4+CD25+ regulatory T cell(CD4+CD25+Tr cell),plasma IL-17 levels,and infection incidence were detected in both groups.Results Compaired with control group,treatment group could significantly decrease 24h urine protein,SLEDAI score,infection rate and down-regulate the level of CD8+T cell(P0.05);but there was no significant difference in up-regulating CD4+CD25+Treg cell and decreasing plasma IL-17 in both groups(P0.05).Conclusion Bushen Gujing Decoction plus high-dose Astragalus injection can significantly ameliorate LN of spleen-kidney yang-deficiency by correcting immune dysfunction." @default.
- W2349814274 created "2016-06-24" @default.
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- W2349814274 date "2010-01-01" @default.
- W2349814274 modified "2023-09-24" @default.
- W2349814274 title "Effects of Bushen Gujing Decoction plus high-dose Astragalus injection on immunological condition in patients with lupus nephritis of spleen-kidney yang-deficiency" @default.
- W2349814274 hasPublicationYear "2010" @default.
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