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- W2349817259 abstract "Objective To investigate the effect of pravastatin on the proliferation, cell cycle of human colorectal cancer cell line HT-29,Ls-174-T and influence on COX-2 protein expression in vitro.Methods colorectal cancer cells were treated with pravastatin. Proliferation of the cells was detected by MTT assay, cell cycle was measured by flow cytometry (FCM), COX-2 protein expression was detected by immunocytochemistry. Results Pravastatin inhibited HT-29 and Ls-174-T colorectal cancer cell growth in vitro. Pravastatin could arrest HT-29 and Ls-174-T cells in the G0/G1 phase of cell cycle. However, apoptosis in HT-29 and Ls-174-T cells was not obvious. Pravastatin inhibited COX-2 protein expression.Conclusion Pravastatin inhibited HT-29 and Ls-174-T colorectal cancer cell growth in vitro, which may be explained by its inhibitory effect on COX-2 protein expression and arresting HT-29 and Ls-174-T cells at G0/G1 phase of cell cycle." @default.
- W2349817259 created "2016-06-24" @default.
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- W2349817259 date "2006-01-01" @default.
- W2349817259 modified "2023-09-26" @default.
- W2349817259 title "Effects of pravastatin on proliferation and expression of COX-2 protein in colorectal cancer cell lines" @default.
- W2349817259 hasPublicationYear "2006" @default.
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