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- W2349839846 abstract "Objective To detect the expression of survivin in salivary gland neoplasms, to analyse the significance of survivin in the occurance and the development of salivary gland neoplasms, and to analyze the possibility of the application of the tissue chip in the study of salivary gland neoplasms by comparing the tissue chip and regular sections.Methods One hundred and fifteen cases of salivary gland neoplasm were collected. The regular sections and the tissue chip were obtained. The survivin protein of the regular sections and tissue chip were determined using the immunohistochemistry method. The mean optic density was measured in the image analyse system and the data was analysed with the SPSS software.Results Survivin did not expressed in the normal salivary gland tissue. Most of the malignant salivary gland neoplasms became expressed with survivin. The survivin expression was only observed in pleomorphic adenoma in benign salivary gland neoplasms. The MOD were 0.20±0.029, 0.38±0.052, and 0.18±0.021 in the high differentiation group, low differentiation group, and PA group, respectively. The survivin expression was correlated with the lymph node metastasis and with the recurrance in salivary gland carcinoma. Among the 124 spots of tissue array made up, the immunohistochemesty results of regular sections were consistent with that of tissue chip.Conclusion The expression level of survivin perhaps reflects the malignant degree of salivary gland carcinoma. Survivin possibly plays an important role in the occurrence and the development of salivary gland carcinoma. The immunohistochemesty results are cohered between the regular sections and tissue chip. Tissue chip may become an economical and useful tool in the study of salivary gland neoplasms." @default.
- W2349839846 created "2016-06-24" @default.
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- W2349839846 date "2006-01-01" @default.
- W2349839846 modified "2023-09-24" @default.
- W2349839846 title "The immunohistological expression of survivin in salivary gland neoplasms" @default.
- W2349839846 hasPublicationYear "2006" @default.
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