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- W2349842007 abstract "Objective:To investigate the mechanism of inducing apoptosis by clotrimazole(CLO),a inhibitor of the intermediate-conductance Ca2+-activated K+(IK) channel.Method:The level of intracellular free Ca2+ was observed with confocal laser scanning microscope.Flow cytometry was used to examine mitochondrial membrane potential.Result:CLO increased the levels of i in NB4. The sensitivity of intracellular stores to thapsigargin had been depleted by clotrimazole.5 μmol/L CLO could reduce the mitochondria membrane potential to 1.9±0.1 and 2.1±0.1 folds of control in 48 h and 72 h.The activity of caspase-3 increased to 1.9±0.2,2.7±0.4,3.3±0.6 folds of control in 12 h,16 h and 20 h.Conclusion:CLO,a inhibitor of IK channel,induced apoptosis of NB4 cells by decreasing intracellular mitochondrial membrane potential and increasing Ca2+ level." @default.
- W2349842007 created "2016-06-24" @default.
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- W2349842007 date "2011-01-01" @default.
- W2349842007 modified "2023-09-23" @default.
- W2349842007 title "Relation ship between clotrimazole-induced apoptosis and calcium homeostasis and mitochondrial membrane potential in human acute myeloid leukemias cells" @default.
- W2349842007 hasPublicationYear "2011" @default.
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