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- W2349849854 abstract "Objective To compare the effect of pure oxygen resuscitation with that of room-air resuscitation on myocardial cell apoptosis and expressions of Bcl-2 and Bax protein using the neonatal rat model of asphyxia. Methods The neonatal SD rat model of asphyxia was established for 2.5 h and the rats were then divided into normal control group, group with pure oxygen resuscitation (PO group), and group with room-air resuscitation (RA group). Pathological changes of the myocardial tissues were microscopically observed using HE staining 24 h and 72 h after resuscitation. Apoptotic index of the myocardial cell was detected by TUNEL assay,and expressions of Bcl-2 and Bax protein in the myocardial tissues were detected by immunohistochemistry (S-P method). Results As compared with those in the normal control group, in PO group most myocardial fibers were swelling and some were ruptured and myocardial interstitial and venules were apparently congested,in RA group, however, myocardial fibers showed obvious flake-like or focal necrosis. There was no significant difference in the present of pathological changes between the two groups. The apoptotic index was markedly greater in RA group than in PO group, with the highest level at 24 h. The expression of Bcl-2, an anti-apoptotic gene, was stronger in PO group than in RA group whereas the expression of Bax, a pro-apoptotic gene, was significantly weaker. Conclusions Myocardial cell apoptosis is more serious using room-air resuscitation than pure oxygen resuscitation, especially 24 hours after resuscitation. Room-air resuscitation promotes the upregulation of Bax expression and pure oxygen enhances the upregulation of Bcl-2 expression, suggesting that a higher concentration of oxygen plays a role in protection of the myocardial cell after asphyxia." @default.
- W2349849854 created "2016-06-24" @default.
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- W2349849854 date "2008-01-01" @default.
- W2349849854 modified "2023-09-23" @default.
- W2349849854 title "Effects of pure oxygen and room-air resuscitation on myocardial cell apoptosis and expressions of Bcl-2 and Bax protein in neonatal rats after asphyxia" @default.
- W2349849854 hasPublicationYear "2008" @default.
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