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- W2349850388 abstract "Objective:To investigate the mechanism for the apoptosis-inducing effect of d-limonene on human leukemia cells.Methods:This study investigated the effects of d-limonene on the proliferation of K562 and HL-60 cells using MTT assay and trypan blue staining method.Apoptosis was evaluated by annexin Ⅴ/PI double-staining.Flow cytometry and Western blotting were performed to evaluate expression of the mitochondria-apoptosis pathway-related proteins.Results:d-limonene induced apoptosis of K562 and HL-60 cells in a dose-and time-dependent manner.The inhibitory effects reached the peak at 72 h(71.21%) after treatment with d-limonene at 0.4 mmol/L.The ratio of Bcl-2/Bax decreased from 1.93 to 0.75.The release of cytochrome c from mitochondria increased of caspase-9 and cleavage of caspase-3 were elevated.Conclusion:d-Limonene induces apoptosis of human leukemia cells.The activation of mitochondria apoptosis pathway may be the main mechanism for the effects of d-limonene on apoptosis of human leukemia cells." @default.
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- W2349850388 date "2008-01-01" @default.
- W2349850388 modified "2023-09-22" @default.
- W2349850388 title "The mechanism underlying apoptosis-inducing effects of d-limonene on human leukemia cells" @default.
- W2349850388 hasPublicationYear "2008" @default.
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