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- W2349864948 abstract "HBV S gene’s mutation lead to failure in hepatitis B vaccine.Long-term immune pressure promote mutation, and HBV mutation is related to its subtypes and genotypes,too. Lacking of HBV standard gene sequence in home can affect accuracy of determinant to the mutants. Routine-clinical kits can not get positive result to some HBV mutants,so it’s necessary to use polyclonal antibody or to find new kits to detect the mutation of HBsAg. Some HBV mutant’s antigenic or immunogenicity is different from wild type HBsAg,for exemple 145Arg,129Leu mutation,etc., the characteristics of infectivity,pathogenecity, and epidemiology of HBV mutants need to be studied in the future." @default.
- W2349864948 created "2016-06-24" @default.
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- W2349864948 date "2005-01-01" @default.
- W2349864948 modified "2023-09-24" @default.
- W2349864948 title "Research of Hepatitis B Virus Gene S Mutation" @default.
- W2349864948 hasPublicationYear "2005" @default.
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