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- W2349865047 abstract "Objective To explore the change of activity of signal transducer and activator of transcription-1 (STAT-1) in pancreatic tissue in rats with severe acute pancreatitis (SAP). Methods 36 male Wistar rats were divided into sham-operation group (SO group, n = 18) and SAP group (n = 18), which was induced by retrograde bile-pancreas duct injection of 5% sodium taurocholate (0.1 mL / 100 g). Rats in each group were sacrificed at 3,6 and 12 h after operation, the serum level of amylase (AMY) was detected, the pathologic changes of pancreatic tissue were detected by HE stain, and the expression of phosphorylated STAT-1 protein in pancreatic tissue was assayed by immunohistochemistry. Results As compared with SO group, the serum level of AMY was increased and the pathologic injury of pancreatic tissue was aggravate with times (P 0.01), the expression of phosphorylated STAT-1 protein was significantly higher (P 0.01) and peaked at 3 h after operation in SAP group. Conclusion Activated STAT-1 protein in pancreatic tissue may play an important role in the pathogenesis of severe acute pancreatitis." @default.
- W2349865047 created "2016-06-24" @default.
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- W2349865047 date "2009-01-01" @default.
- W2349865047 modified "2023-09-28" @default.
- W2349865047 title "Change of activity of STAT-1 in pancreatic tissue in rats with severe acute pancreatitis" @default.
- W2349865047 hasPublicationYear "2009" @default.
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