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- W2349888901 abstract "Objective:To explore the induced effects of 12-tetradecanoyl-phorbol-13-acetate (TPA) on the mtDNA mutation in the ovary cancer cell SKOV3.Methods:DNA was extracted from the SKOV3 cells,then mtDNA mutation was analyzed.The mtDNA mutation rate and type were compared in different groups.Results:The mutational hot spots of mtDNA were Co Ⅱ gene,ND5 gene,Cytb gene and ND4 gene in turn.There were multiple genetic mutations by mtDNA sequencing.The main mutation types were A→T ,T→A,G→A,T→C,A→G,C→T.The C→T mutation was the hot point of mtDNA mutation.Conclusions:Cytb gene mutation might have a significant influence on the oxidative phosphorylation of mitochondria.The mtDNA gene of CoⅡ,Cytb,ND4,ND5 are the highly polymorphic and mutable region in ovary cancer cell SKOV3 that there may be some relations with ovary carcinogenesis and development." @default.
- W2349888901 created "2016-06-24" @default.
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- W2349888901 date "2011-01-01" @default.
- W2349888901 modified "2023-09-28" @default.
- W2349888901 title "Mitochondrial DNA Mutation in Ovary Cancer Cell SKOV3 by 12-Tetradecanoyl-Phorbol-13-Acetate" @default.
- W2349888901 hasPublicationYear "2011" @default.
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