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- W2349893450 abstract "Objective To investigate the protective effect of eukaryotic expression vectors for mp65 and sap2 genes on systemic Candida albicans infection in mice.Methods BALB /c mice were immunized with plasmids pcDNA3.1-mp65 and pcDNA3.1sap2 separately or in combination.The specific IgGs against MP65 and Sap2 proteins in peripheral blood of immunized mice were determined by ELISA,and the percentages of CD4+ and CD8+ T lymphocytes in spleens by flow cytometry.The survival rate of immunized mice after challenge with Candida albicans was observed.Results The specific IgGs against MP65 and Sap2 proteins were detected in peripheral blood of immunized mice.Both the plasmids increased the percentage of CD4+ T lymphocytes in spleen and the survival rate of mice after systemic infection with Candida albicans.Conclusion Plasmids pcDNA3.1-mp65 and pcDNA3.1-sap2 induced humoral immune response and CD4+ T lymphocyte-mediated cellular immune response in mice,and showed a certain protective effect against systemic infection with Candida albicans." @default.
- W2349893450 created "2016-06-24" @default.
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- W2349893450 date "2010-01-01" @default.
- W2349893450 modified "2023-09-26" @default.
- W2349893450 title "Eukaryotic Expression Vectors for mp65 and sap2 Genes Protects Mice against Systemic Candida albicans Infection" @default.
- W2349893450 hasPublicationYear "2010" @default.
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