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- W2349915095 abstract "Objective To investigate the expression of stem cell marker aldehyde dehydrogenase1(ALDH1) and its correlation with the clinical characteristics of breast invasive ductal cancer.MethodsWe performed immunohistochemistry to detect ALDH1 expression on breast cancer tissue microarray including 85 breast invasive ductal cancer tissues.Results 22 cases(25.9%) in the 85 breast invasive ductal cancer tissues were ALDH1 positive,though 17 of the 22 cases expressed ALDH1 at a low level.The expression frequency of ALDH1 in ER negative breast cancer was higher than that in ER positive breast cancer(34.6% vs 12.1%;P=0.024).ALDH1 expression differed among distinct subtypes of breast cancer,with a higher rate of positivity in triple-negative breast cancer(TNBC)(50.0%,P=0.034).Different expression of ALDH1 was also found in tumors with different sizes,among which tumors smaller than 2cm showed elevated expression of ALDH1(50.0%;P=0.040).Moreover,ALDH1 expression was not associated with age,tumor grade,lymph node status,stage,PR and HER-2 status(P0.05).ConclusionsHigher expression of ALDH1 was mainly found in ER negative breast cancer,expecially in TNBC,suggesting a higher proportion of cancer stem cells in this kind of breast cancer.These data may be clinically useful for a better understanding of the poor prognosis of the patients with ER negative breast cancer." @default.
- W2349915095 created "2016-06-24" @default.
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- W2349915095 date "2012-01-01" @default.
- W2349915095 modified "2023-09-23" @default.
- W2349915095 title "Expression of aldehyde dehydrogenase1(ALDH1) is associated with ER negative breast cancer" @default.
- W2349915095 hasPublicationYear "2012" @default.
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