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• W2349918789 startingPage "37" @default.
• W2349918789 abstract "Immediate-early genes (IEGs) can be activated and transcribed within minutes after stimulation, without the need for de novo protein synthesis, and they are stimulated in response to both cell-extrinsic and cell-intrinsic signals. Extracellular signals are transduced from the cell surface, through receptors activating a chain of proteins in the cell, in particular extracellular-signal-regulated kinases (ERKs), mitogen-activated protein kinases (MAPKs) and members of the RhoA-actin pathway. These communicate through a signaling cascade by adding phosphate groups to neighboring proteins, and this will eventually activate and translocate TFs to the nucleus and thereby induce gene expression. The gene activation also involves proximal and distal enhancers that interact with promoters to simulate gene expression. The immediate-early genes have essential biological roles, in particular in stress response, like the immune system, and in differentiation. Therefore they also have important roles in various diseases, including cancer development. In this paper we summarize some recent advances on key aspects of the activation and regulation of immediate-early genes." @default.
• W2349918789 created "2016-06-24" @default.
• W2349918789 creator A5015108785 @default.
• W2349918789 creator A5022164078 @default.
• W2349918789 date "2016-09-01" @default.
• W2349918789 modified "2023-10-12" @default.
• W2349918789 title "Gene regulation in the immediate-early response process" @default.
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