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- W2349951504 abstract "Objective To investigate the radiosensitivity effect of compound radix sophora flavescens injection(CRSFI) combined with radiotherapy for Lewis lung cancer cell lines in vitro.Methods Lung cancer xenograft model was established in C57BL/6 mice,the mice were randomly divided into control group,CRSFI group,radiotherapy group and combined treatment group,10 cases in each group,control group were intraperitoneally injected with 0.9% saline solution,CRSFI group were intraperitoneally injected with CRSFI,radiotherapy group were only treated with radiotherapy,combined treatment group were intraperitoneally injected with CRSFI combined with radiotherapy,subcutaneous tumor volume was detected regularly,mice were killed 27 d after inoculation.The tumor mass,volume and pulmonary metastasis number of mice were compared,the number of lung metastatic tumor nodules.VEGF immunohistochemistry score and microvessel density(MVD) of tumor tissues and lung tissues were detected.Results 12 and 15 d after inoculation,there was no significant difference in tumor volume among control group,CRSFI group,radiotherapy group and combined treatment group(P0.05);18,21,24,27 d after inoculation,tumor volumes in CRSFI group,radiotherapy group and combined treatment group were smaller than that of control group,the differences were statistically significant(P0.05);18,21,24,27 d after inoculation,tumor volume in combined treatment group was smaller than those of CRSFI group and radiotherapy group,the differences were statistically significant(P0.05);21,24,27 d after inoculation,tumor volume in radiotherapy group was smaller than that of CRSFI group,the difference was statistically significant(P0.05).Compared with the control group,CRSFI group,pulmonary metastasis number and mass in CRSFI group,radiotherapy group and combined treatment group were decreased,the differences were statistically significant(P0.05);Compared with CRSFI group,pulmonary metastasis number and mass in radiotherapy group and combined treatment group were decreased,but the tumor inhibition rates in the above two groups were increased,the differences were statistically significant(P0.05);Compared with radiotherapy group,tumor mass in combined treatment group were decreased,but tumor inhibition rate in combined treatment group was increased,the differences were statistically significant(P0.05).There were significant differences in VEGF immunohistochemical scores and MVD among 4 groups(P0.05).Compared with control group,VEGF immunohistochemical scores and MVD of CRSFI group,radiotherapy group and combined treatment group were decreased,the differences were statistically significant(P0.05).Conclusion For the C57BL/6 mice Lewis lung carcinoma xenograft model,CRSFI combined with radiotherapy can inhibit tumor growth and metastasis,prolong survival time of mice,improve curative effect of radiotherapy.CRSFI combined with radiotherapy may be an effective and unique anti-tumor therapy." @default.
- W2349951504 created "2016-06-24" @default.
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- W2349951504 date "2013-01-01" @default.
- W2349951504 modified "2023-09-23" @default.
- W2349951504 title "Radiosensitivity Effect of Compound Radix Sophora Flavescens Injection Combined with Radiotherapy for Lewis Lung Cancer Cell Lines in Vitro" @default.
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