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- W2349964444 abstract "TCF7L2 is the key transcriptional factor regulating glucose metabolism through the Wnt signaling pathway.Insulin-degrading enzyme(IDE) plays a key role in insulin degradation in celluar level and is closely related to hyperglycemia,insulin resistance as well as hyperinsulinemia in patients with Type 2 dia-betes mellitus(T2DM).To identify the region in IDE gene promoter where the transcriptional factor TCF7L2 can bind in HePG2 cells.Chromatin immunoprecipitation and PCR were performed using the antibody spe-cific for TCF7L2 to verify the binding of TCF7L2 to IDE promoter.Results indicated that IDE gene specif-ic fragments were detected in the DNA fragments immunoprecipitated by antibody specific for TCF7L2.Thus it proved that TCF7L2 protein could bind to the promoter regions of IDE gene in HePG2 cells and may in-volved in regulation of IDE gene expression." @default.
- W2349964444 created "2016-06-24" @default.
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- W2349964444 date "2012-01-01" @default.
- W2349964444 modified "2023-09-24" @default.
- W2349964444 title "Detection of TCF7L2 Binding to IDE Gene Promoters by Chromatin Immunoprecipitation" @default.
- W2349964444 hasPublicationYear "2012" @default.
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