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- W2349966858 abstract "Objective To evaluate the underlying mechanisms of Hep 3B cell apoptosis induced by JS-K, a non-ionic diazeniumdio late derivative of nitric oxide (NO) donor. Methods The activities of mitogen-activated protein kinases (MAPKs), active protein 1 (AP-1) and apoptosis were studied with Western blotting, immonoprecipatation, and electrophoretic mobility shift assay (EMSA) in Hep 3B cell line. Results NO induced activation of extracellular-signal-regulated protein kinase (ERK), c-Jun N-terminal kinase (JNK) and p38 kinase, especially ERK persistent activation, and also induced activation of AP-1. AP-1 activation and apoptosis of Hep 3B cell line was partially abolished by U0126 and JNK inhibitor II, inhibitors of ERK and JNK, but not by SB203580, a inhibitor of p38 kinase, indicating that ERK and JNK activation involved the AP-1 activation and apoptosis induced by JS-K in Hep 3B cell line. Conclusion JS-K induces Hep 3B cell line apoptosis through ERK and JNK activation, which further activated AP-1." @default.
- W2349966858 created "2016-06-24" @default.
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- W2349966858 date "2004-01-01" @default.
- W2349966858 modified "2023-09-25" @default.
- W2349966858 title "The Hep 3B cell apoptosis induced with nitric oxide mediated through mitogen-activated protein kinases through various of approaches" @default.
- W2349966858 hasPublicationYear "2004" @default.
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