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- W2349969196 abstract "Objective:To investigate the individual serum tauro-conjugated bile acid concentration in patients with Intrahepatic Cholestasis of Pregnancy(ICP) by high performance liquid chromatography-tendem mass spectro-metry(HPLC-MS/MS).Methods:Bile acids were extracted from serum samples of ICP,ICP with Diabetes Mellitus,ICP with Virus Hepatitis patients and normal pregnant women.Serum tauro-conjugated bile acids were measured by HPLC-MS/MS.Results:The serum levels of taurocholic acid(TCA),taurochenode-oxycholic acid(TCDCA) and taurodeoxycholic acid(TDCA) in the three groups of ICP,ICP with Diabetes Mellitus,and ICP with Virus Hepatitis were significantly higher than those of the control group(P0.01),and the differences and were 15-fold,5-fold,3-fold,respectively.The serum levels of TCA and TCDCA were statistically different among each two of patients of ICP,ICP with Diabetes Mellitus,ICP with Virus Hepatitis respectively(P0.05).Conclusion:The concentrations of individual tauro-conjugated bile acids have specific features in ICP patients." @default.
- W2349969196 created "2016-06-24" @default.
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- W2349969196 date "2009-01-01" @default.
- W2349969196 modified "2023-09-22" @default.
- W2349969196 title "Simultaneous determination of serum tauro-conjugated bile acids in intrahepatic cholestasis of pregnancy patients by high performance liquid chromatography-tendem mass spectrometry" @default.
- W2349969196 hasPublicationYear "2009" @default.
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