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- W2349969861 abstract "Objective To research the relationship between DNA gyrase,topoisomerase Ⅳ and Stenotrophomonas maltophilia to fluoroquinolone resistance.Methods 19 resistant strains with negative for efflex mechanism and 10 sensitive strains were selected to amplify their quinolone resistence determining regions of gyrA and parC,and to analyze the nucleotide sequence.The data were analyzed by SPSS software.Results Of 19 strains of Stenotrophomonas maltophilia to fluoroquinolone resistance strains of gyrA gene and parC gene,7 strains were observed the nucleoside changes in each,while those base subtitutions were same sense mutation.2 strains showed amino acid changes in position 124 leading to substitution Glu by Asp(GAA→GAC),the same amino acid mutation was found in the controls.No significant difference was found between 2 groups(P0.05).Conclusions Fluoroquinolone resistance in Stenotrophomonas maltophilia is related to active effax pump,and it may be correlated with a low level of permeability,but not asscociatad with gyrase and topoisomerase Ⅳ." @default.
- W2349969861 created "2016-06-24" @default.
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- W2349969861 date "2011-01-01" @default.
- W2349969861 modified "2023-09-26" @default.
- W2349969861 title "Investigation of the fluoroquinolone molecular resistant mechanism of Stenotraphomonas maltophilia" @default.
- W2349969861 hasPublicationYear "2011" @default.
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