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- W2349973313 abstract "AIM: To explore the effects of psoralen plus ultra- violet A(PUVA)on NB_4 cells and K_ 562 cells. METHODS: NB_4 cells and K_ 562 cells were subjected to the research.The effects of psoralen extracted from Chinese medicine plus ultraviolet A(UVA) of wave length 360 nm on leukemia cell lines were observed. The factorial design was applied to observe the effects of psoralen at different concentrations, UVA with different exposure time, on the inhibition rates and apoptosis rates of different leukemia cell lines, and the interaction among the each factor. RESULTS: ①When the concentration of psoralen was 80 mg/L and the exposure time of UVA was 15 min,the inhibition rates of NB_4 cells reached the peak. When the concentration of psoralen was 80 mg/L and the exposure time of UVA was 10 min, the inhibition rates of K_ 562 cells reached the peak. ②When the concentration of psoralen was 40 mg/L and exposure tim of UVA was 10 min,the apoptosis rates of NB_4 cells reached the peak. When the concentration of psoralen was 80 mg/L and exposure time of UVA was 15 min,the apoptosis rates of K_ 562 cells reached the peak. ③The inhibition rates and the apoptosis rates of different leukemia cell lines induced by psoralen at different concentrations plus UVA with different exposure time had statistical differences, and there was the interaction between each factor. CONCLUSION: PUVA can inhibit the growth of NB_4 and K_ 562 cell lines and induce their apoptosis. The most effective point of PUVA on NB_4 and K_ 562 cell lines is that the concentration of psoralen is 40-80 mg/L and the exposure time of UVA is 10-15 min." @default.
- W2349973313 created "2016-06-24" @default.
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- W2349973313 date "2006-01-01" @default.
- W2349973313 modified "2023-09-22" @default.
- W2349973313 title "Effects of psoralen plus ultraviolet A on NB_4 and K_(562) leukemia cell lines" @default.
- W2349973313 hasPublicationYear "2006" @default.
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