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- W2350012407 abstract "To investigate the relationship between penA/ponA and penicillin resistance of Neisseria gonorrhoeae.Agar dilution method was used to determine the minimum inhibitory concentrations (MICs) of the strains. Polymerase chain reaction-single stand conformation polymerphism (PCR-SSCP) and PCR- restriction fragment length polymorphism (RFLP) were used to detect the mutations in ponA and penA genes, which encoding the penicillin binding protein-1 and -2 (PBP1 and PBP2), respectively.All the 80 N. gonorrhoeae isolates had a D345 insertion detected in penA while 93.7% of N. gonorrhoeae isolates having a point mutation Leu421 --> Pro in ponA. Most of the penicillinase producing N. gonorrhoeae (PPNG) strains possessed the mutations in ponA and penA.Our data suggested that the plasmid and chromosome mediated penicillin-resistance conjugately increased the level of resistance." @default.
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- W2350012407 date "2007-09-01" @default.
- W2350012407 modified "2023-09-22" @default.
- W2350012407 title "[Study on the correlation between gene ponA/penA and the penicillin-resistance of Neisseria gonorrhoeae]." @default.
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