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- W2350050394 abstract "Objective To evaluate the effectivenss and safety of Koukuiqing buccal tablets in the treatment of recurrent aphthae( brimming heat of heart and spleen). Methods A randmized,double- blinded,single- imitated,placebo parallel- controlled multicenter clinical trial was conducted,including 80 cases in low dose group,high dose group and placebo group,respectively. The healing rate and healing time,clinical signs and symptoms in 5 day,Chinese medical syndrome in 5 day,visual analogue scale( VAS) score before and after treatment were compared among three groups. Results There were 80,78 and 78 cases in low dose group,high dose group and the placebo group completed the trial,respectively. Compared with the placebo group,ulcer cure rates of low and high dose group were significantly higher,and mediate healing time were shorter. The total effective rate of clinical signs and symptoms,Chinese medical syndrome are significantly higher in low and high dose groups,while pain scores decreas significantly in the two group after treatment. Low and high dose group were superior to placebo in evaluation of curative effect( P 0. 01),but low and high dose group showed no significant difference( P 0. 05). The incidence of adverse events in three groups were very low and showed no significant difference( P 0. 05). Conclusion Low dose group and high dose group have similar treatment effectiveness and safety of recurrent aphthae,overall we recommend low dose for the treatment of recurrent aphtha,0. 5 g each time,4 times a day." @default.
- W2350050394 created "2016-06-24" @default.
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- W2350050394 date "2013-01-01" @default.
- W2350050394 modified "2023-09-24" @default.
- W2350050394 title "Clinical trial of Koukuiqing buccal tablets in the treatment of recurrent aphthae" @default.
- W2350050394 hasPublicationYear "2013" @default.
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