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- W2350062015 abstract "Objective:To explore the expression of intercellular adhesion molecule-1(ICAM-1) protein in cerebral cortex of neonatal rats after hypoxic-ischemic brain damage(HIBD) and the intervention effect of simvastatin.Methods:144 SD rats of 7-day-old were selected randomly and divided into sham operation group,normal saline group,citicoline group and simvastatin group,6 time points subgroups(0,12,24,48,72 hours and 7 days) were included into each group,6 rats in each subgroup,HIBD models were constructed by Rice method,and intervention measures were conducted in each subgroups at the same time,the left common carotid artery of sham operation group were dissociated without ligation,the rats in sham operation group did not receive any other treatments;the cerebral cortex of ligation side were removed and ligated at different time points,immunohistochemical method was used to detect the expression of ICAM-1 at ligation side,and the results were compared among different subgroups.Results:ICAM-1 did not express in normal saline group,the expression rate of ICAM-1 protein in cerebral cortex of ligation side in sham operation group was low,there was no significant difference among different subgroups(F=2.434,P0.05);the expression levels of ICAM-1 protein in normal saline group,citicoline group and simvastatin group increased significantly at 12 hours after HIBD,achieved peak at 24 hours,then decreased;at 7 days after HIBD,the positive rates of ICAM-1 protein in normal saline group and citicoline group were significantly higher than that in sham operation group(P0.01);at 12,24,48 and 72 hours after HIBD,the positive rate of ICAM-1 protein in simvastatin group was significantly lower than that in normal saline group;at 7 days after HIBD,there was no significant difference between simvastatin group and sham operation group(P0.05);at 72 hours and 7 days,the positive rates of ICAM-1 protein in simvastatin group were significantly lower than those in citicoline group(P0.05 or P0.01).Conclusion:Simvastatin and citicoline play protective effects in rats with HIBD,the mechanism is related to regulation of ICAM-1,and the regulative effect of simvastatin is superior to citicoline." @default.
- W2350062015 created "2016-06-24" @default.
- W2350062015 creator A5083435355 @default.
- W2350062015 date "2010-01-01" @default.
- W2350062015 modified "2023-09-25" @default.
- W2350062015 title "Expression of intercellular adhesion molecule-1 protein in cerebral cortex after hypoxic-ischemic damage and its significance" @default.
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