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- W2350071993 abstract "Objective To investigate the effect of selective sinomenine and cisplatin on the proliferation in human cervical cancer cell Hela.Methods The proliferation of cells were detected by MTT methods.The distribution of cell cycle and the rate of apoptosis were determined by flow cytometry.The expression of Maspin,Caspase-3 and COX-2 protein was detected by immunohisto-chemistry.Comparisons between groups were performed with one-way ANOVA analysis and LSD-t test.Results Sinomenine could inhibit the proliferation of Hela cells as direct relation of concentrations and times,combined use of sinomenine and cisplatin could enhance the apoptosis rate and down-regulate the expression of Caspase-3 and COX-2 protein and up-regulate the expression of Maspin protein.Conclusion Sinomenine could inhibit proliferation and induce apoptosis in human uterine cervix cancer cells.Sinomenine combined with cisplatin may be synergistically inhibitory for proliferation of cervical cancer Hela cells." @default.
- W2350071993 created "2016-06-24" @default.
- W2350071993 creator A5011912764 @default.
- W2350071993 date "2010-01-01" @default.
- W2350071993 modified "2023-09-24" @default.
- W2350071993 title "The effect of sinomenine and cisplatin on cell proliferation of human cervical cancer cell line Hela" @default.
- W2350071993 hasPublicationYear "2010" @default.
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