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- W2350083553 abstract "Objective To investigate the relationship between concentrations of IL-8 in vaginal discharge and adverse pregnant outcome in women with lower genital tract infection. Methods Vaginal discharge was obtained from the observative group of 255 pregnant women with Fungal,Trichomonas vaginalis,Chlamydia trachomati (CT) ,Ureaplasma urealyticum (UU),Mycoplasma hominis(MH) or Bacteria vaginosis(BV). The concentrations of IL-8 were determined by enzyme-linked immunosorbent assay (ELISA). Pathological study and bacterial detection were performed in fetal and placental tissue in women with adverse pregnant outcomes . The control group included 120 pregnant women without lower genital tract infection. Results (1) The levels of IL-8 in observative group A in first,second and third trimester were (222.9±193.6)ng/L,(320.0±163.9) ng/L and (423.1±115.9)ng/L respectively. The levels of IL-8 in control group were (125.0±45.3) ng/L ,(269.0±59.5) ng/L and (359.0±107.1) ng/L respectively. There were significant differences between the two groups (P0.01). (2) When the level of IL-8 increased over than 800 ng/L,78.13%(25/32) of the observation group B had adverse pregnant outcomes, while 5.26%(2/38) in the observation group B with antibiotic treatment. There were significant differences between these two groups (P0.001). (3) The same microorganisms were detected in the tissues and the chorioamnionitis were proved by pathology. Conclusion The IL-8 concentrations of vaginal fluid has close relationship with lower genital tract infection and chorioamnionitis. The level of IL-8 in vaginal discharge can be used as a marker of subclinical intraamniotic infection of the pregnant women with lower genital tract infection." @default.
- W2350083553 created "2016-06-24" @default.
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- W2350083553 date "2004-01-01" @default.
- W2350083553 modified "2023-09-22" @default.
- W2350083553 title "Relationship between concentration of IL-8 in vaginal discharge and adverse pregnancy outcomes in women with lower genital tract infection" @default.
- W2350083553 hasPublicationYear "2004" @default.
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