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- W2350094234 abstract "Objective To investigate the association between the-765GC of cyclooxygenase-2(COX-2)genetic polymorphism and susceptibility to gastric cancer(GC)by conducting a meta-analysis.Methods Publications addressing the relationship between the-765GC of COX-2 genetic polymorphism and susceptibility to GC were selected from the MEDLINE,EMBASE,CBMdisc databases on computer and relevant journals were searched manually.Data were extracted and cross-checked from the case-control studies by 2 independent reviewers.The meta-analyses were performed by RevMan 5.0.23.Results Eight studies were enrolled reporting a total of 3880 patients,in which 1617 patients were included in the study group,2263 patients were included in the control group.The final result showed that carriers of-765C allele revealed an enhanced risk for GC[OR=1.71,95%CI:1.01-2.90,P =0.05].Analysis of the subgroup showed a significant association between the-765C allele and GC in Asians(OR=1.87,95%CI= 1.19-2.94,P =0.006)and Indians(OR=8.38,95%CI= 4.34-16.16,P 0.000 01),although no significant association was found in the Caucasians.In the Dutch-765G allele was also found to be an enhanced risk of GC through the subgroup analysis[OR=0.53,95%CI= 0.33-0.87,P 0.000 01].Conclusion The genetic polymorphism of-765C allele of COX-2 was associated with susceptibility to gastric cancer(GC),which differs in different ethnicities." @default.
- W2350094234 created "2016-06-24" @default.
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- W2350094234 date "2011-01-01" @default.
- W2350094234 modified "2023-09-22" @default.
- W2350094234 title "Genetic Polymorphism of-765G>C of Cyclooxygenase-2 and Susceptibility to Gastric Carcinoma:A Meta-analysis" @default.
- W2350094234 hasPublicationYear "2011" @default.
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