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- W2350097117 abstract "Objective To investigate the intervention effect of recombinant hirudin on inflammatory reaction in perihematoma of rats with intracerebral hemorrhage(ICH).Methods ICH models of rats were established by autologous blood injection. Recombinant hirudin was injected into hematoma immediately, 6 h, 12 h after operation, then the expressions of TNF-α and ICAM-1 were detected and myeloperoxidase (MPO) activity was measured in perihematoma.Results TNF-α immune reaction cells, ICAM-1 positive micro-vessels and MPO activity in perihematoma all increased strongly 3 d after ICH ( P0.01). All of the three indexes were decreased significantly whether recombinant hirudin was injected immediately or 6 h after ICH ( P0.01 or P0.05), while there was no significant change of them if recombinant hirudin was injected 12 h after ICH.Conclusions Thrombin takes a role on inflammatory reaction in intracerebral hemorrhage, probably involving the expression of TNF-α and ICAM-1. The infiltration of leukocytes in perihematoma may be reduced if recombinant hirudin is given within 6 h after ICH." @default.
- W2350097117 created "2016-06-24" @default.
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- W2350097117 date "2005-01-01" @default.
- W2350097117 modified "2023-09-22" @default.
- W2350097117 title "Intervention effect of recombinant hirudin on inflammatory reaction in perihematoma of rats with intracerebral hemorrhage" @default.
- W2350097117 hasPublicationYear "2005" @default.
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