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- W2350098965 abstract "Objective:To identify the characteristics of airway inflammation in patients with positive bronchodilator reversibility testing during stable stage of COPD.Methods:Sixty-three patients with stable COPD were selected.Lung function and bronchodilator reversibility testing were performed and cellular differential count and levels of eosinophil cationic protein(ECP),myeloperoxidase(MPO),interleukin-5(IL-5),and interleukin-8(IL-8) in induced sputum were measured by Wrights' stain,Immuno-CAP System,and ELISA,respectively.Thirty patients with asthma during the exacerbation period and twenty healthy subjects were selected as control.Results:Of sixty-three patients with stable stage of COPD,15 cases(23.8%) showed positive bronchodilator reversibility testing.The percentage of eosinophil(EOS)([4.9 ± 2.1] %) and level of ECP([121.3 ± 60.2] μg/L) in induced sputum in patients with positive bronchodilator reversibility testing during stable stage of COPD were higher than those in patients with negative bronchodilator reversibility testing during stable COPD(all P0.05) and in healthy subjects(all P0.01) respectively.The level of IL-5([14.6±8.1] μg/L) in induced sputum in patients with positive bronchodilator reversibility testing during stable stage of COPD were lower than that in patients with asthma(P0.01) and there was no difference in level of IL-5 in induced sputum between healthy subjects,patients with positive and negative bronchodilator reversibility testing during stable stage of COPD(all P0.05).The percentage of neutrophil,levels of MPO,and IL-8([58.1±14.3]%,[521.9±98.5] μg/L,and [30.2±12.7] μg/L) in induced sputum in patients with positive bronchodilator reversibility testing during stable stage of COPD were higher than those in patients with asthma and healthy subjects(all P0.01).There was no difference in percentage of neutrophil,levels of MPO,and IL-8 in induced sputum between patients with positive and negative bronchodilator reversibility testing during stable stage of COPD(all P0.05).Conclusion:The patients with positive bronchodilator reversibility testing in stable stage of COPD may present not only eosinophilic airway inflammation but also neutrophilic airway inflammation." @default.
- W2350098965 created "2016-06-24" @default.
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- W2350098965 date "2010-01-01" @default.
- W2350098965 modified "2023-09-23" @default.
- W2350098965 title "Clinical Significance of Inflammatory Markers in Induced Sputum from Patients with Positive Bronchodilator Reversibility Testing During Stable Stage of COPD" @default.
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