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- W2350111600 abstract "Background and purpose:Circulating endothelial progenitor cells(cEPCs) play an important role in neovascularisation and tumor growth.This article aimed to study the impact of chemotherapy on the amounts of cEPCs in peripheral blood of advanced non-small cell lung cancer(NSCLC) patients.Methods:Thirty-five patients with advanced NSCLC were enrolled.Fresh blood samples were obtained during cisplatin plus paclitaxel based chemotherapy,1 day before,7,15,and 42 days after chemotherapy respectively,and were tested using multiparametric flow-cytometry.cEPCs were defined as CD34~+/CD133~+/VEGFR-2~+.Response rate and toxicity during two cycles of chemotherapy were recorded.Results:Number of cEPCs changed significantly during chemotherapy.cEPCs on the 15 days after chemotherapy were much more than any of others(SNK Test,F=4.36,P=0.006).Regarding response rate of chemotherapy,cEPCs in the subgroup patients benefited from chemotherapy decreased obviously.The relative change in cEPC numbers between 1 day before and 42 days after chemotherapy,assessment was significantly correlated to the disease condition such as progression or under control(r=0.641,P0.001).Interestingly,cEPCs on the day before chemotherapy of patients benefited from chemotherapy was significantly less than that of patients with tumor progression(t~'=4.46,P0.001).Conclusion:cEPCs in peripheral blood of advanced NSCLC patients are associated with the response rate of chemotherapy." @default.
- W2350111600 created "2016-06-24" @default.
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- W2350111600 date "2011-01-01" @default.
- W2350111600 modified "2023-09-24" @default.
- W2350111600 title "Circulating endothelial progenitor cells in patients with non-small cell lung cancer during chemotherapy" @default.
- W2350111600 hasPublicationYear "2011" @default.
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