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- W2350137577 abstract "Aim:To find out the effects of lead exposure during mouse pregnancy on the expression of IL-β1 protein in cerebral cortex of their offspring.Methods:Lead exposure was conducted through freely drinking the corresponding lead acetate solutions with dosages of 0.3,1.0 and 3.0 g/L,respectively.Each group had 10 mice. 21 days after their birth, the lead contents in blood and cerebral cortex of the offspring were determined.The expression of IL-β1 protein in hippocampus of all the offspring was detected by using immunohistochemistry assay.Results:There were significant differences in lead contents in blood and cerebral cortex(F=53.125 and 10.012,P0.05),and the lead levels in blood and cerebral cortex of experimental groups were higher than those of control group(P0.05). In Morris Maze experiment,there were significant differences in testing mistakes and average escape time(F=303.475 and 26.922,P0.001),and the results of middle-and high-dose groups were higher than those of control group(P0.05).The expression of IL-β1 protein had significant difference among four groups(F=852.913,P0.001).Conclusion: Lead might affect learning and memory and cause nervous system damage through inducing IL-β1 protein expression in the cortex." @default.
- W2350137577 created "2016-06-24" @default.
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- W2350137577 date "2010-01-01" @default.
- W2350137577 modified "2023-09-23" @default.
- W2350137577 title "Effects of maternal lead exposure on IL-β1 protein expression in neonatal mice cerebral cortex" @default.
- W2350137577 hasPublicationYear "2010" @default.
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