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- W2350152437 abstract "OBJECTIVE To investigate the pharmacokinetics of tramadol hydrochloride in Chinese Han healthy volunteers.METHODS 10 Healthy volunteers were given with a single oral dose(100 mg) of Tramadol Hydrochloride Capsule.Blood samples were collected from vein at certain sampling times.Tramadol hydrochloride in plasma were determined by HPLC-fluorescence method,and the pharmacokinetic parameters were calculated by 3P97 software.RESULTS The plasma concentration-time curves of tramadol were fitted to a two-compartment model with a first order absorption.The main pharmacokinetic parameters were as follows: tmax(2.4±0.7) h,ρmax(401.4±77.9) μg·L-1,t1/2α(2.1±1.8)h,t1/2β(6.6±1.2)h,AUC0-36(4 249±1 290)μg·h·L-1,AUC0-∞(4 370±1 347)μg·h·L-1.CONCLUSION The pharmacokinetic parameters of tramadol in healthy volunteers after an oral single dose of tramadol hydrochloride capsule is concordant with that of the literature.There is no significant difference in the pharmacokinetic parameters between female and male subjects." @default.
- W2350152437 created "2016-06-24" @default.
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- W2350152437 date "2008-01-01" @default.
- W2350152437 modified "2023-09-24" @default.
- W2350152437 title "Pharmacokinetics of Tramadol Hydrochloride in Chinese Han Healthy Volunteers" @default.
- W2350152437 hasPublicationYear "2008" @default.
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