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- W2350168275 abstract "Objective To investigate whether the insertion G (1484insG) of protein tyrosine phosphatase-1B (PTP1B) gene is associated with obesity in Chinese. Methods 1484insG of PTP1B gene was determined by PCR/SacII digestion in 305 subjects in Shanghai. All of the mutation samples were performed DNA sequencing analysis. Results 1484insG of PTP1B gene was found in 10 subjects in simple obesity group, 16 subjects in obesity with type 2 diabetes group and 8 subjects in control group. As for the allele frequency, there was significant difference between the obesity with type 2 diabetes group and the control group (P0.05), but no difference was found between any other two groups. Conclusion 1484insG of PTP1B gene is associated with obesity plus type 2 diabetes mellitus in Chinese patients. This variation may be a genetic factor for obese subjects in China to develop type 2 diabetes mellitus." @default.
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- W2350168275 date "2006-01-01" @default.
- W2350168275 modified "2023-09-23" @default.
- W2350168275 title "1484insG mutation of protein tyrosine phosphatase-1B gene is associated with obesity in Chinese" @default.
- W2350168275 hasPublicationYear "2006" @default.
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