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• W2350187513 abstract "The marked dopaminergic deficiency in basal ganglia nuclei is the major biochemical alteration underlying the motor symptoms in Parkinson's disease (Hornykiewicz, 1982). It has been postulated that deficient dopaminergic transmission in the central nervous system is responsible not only for motor impairment but also for some of the cognitive alterations in Parkinson's disease. This assumption is based on several lines of evidence. Some studies have found an improved performance in neuropsychological tests after the commencement of levodopa treatment (Loranger et aI., 1972; Brown et aI., 1984). Other studies have shown a positive correlation between the severity of motor symptoms and the severity of cognitive changes in Parkinson's disease (Mortimer et aI., 1982), suggesting that both cognitive and motor symptoms result from the same pathological changes in the brain. The significant correlation between the severity of motor impairment and the performance in a neuropsychological test battery could be confirmed in another study (Pillon et aI., 1989). However, segregation of the motor symptoms as a function of their response to levodopa leads to a different conclusion. Rigidity and akinesia, both of which respond well to levodopa, were only poorly correlated with performance in the tests. By contrast, symptoms which show little or no response to dopamine replacement such as gait disorder and dysarthria showed strong correlations with neuropsychological test scores. These correlations suggest that cognitive impairment in Parkinson's disease is at least partly related to the dysfunction of non-dopaminergic neuronal systems." @default.
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• W2350187513 date "1990-01-01" @default.
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• W2350187513 title "AND CENTRAL CHOLINERGIC FUNCTION" @default.
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