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- W2350193245 abstract "Objective To investigate the preventive and therapeutic effect of ambroxol (AMB) on acute lung injury (ALI) induced by lipopolysaccharide (LPS) and its mechanism.Methods The change of arterial oxygen partial pressure (PaO_2),wet/dry (W/D) ratio of lung weight and pathology of lung tissue were examined;the change of surfactant protein A (SP-A protein),SP-A mRNA expression were measured with immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR) method respectively.Results The administration of AMB increased PaO_2 significantly,decreased W/D,alleviated the pulmonary tissues damage,and increased the expression of SP-A.Conclusions AMB has a protective effect on ALI by through increasing the expression of SP-A." @default.
- W2350193245 created "2016-06-24" @default.
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- W2350193245 date "2006-01-01" @default.
- W2350193245 modified "2023-09-27" @default.
- W2350193245 title "Effect of Ambroxol on Expression of SP-A in Lung Tissue of ALI Rats Induced by LPS" @default.
- W2350193245 hasPublicationYear "2006" @default.
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