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- W2350198452 abstract "Objective To study HIV-1 genotypes and transmitted drug resistance( TDR) among antiretroviral treatment( ART)-nave HIV-infected pregnant women in Yunnan. Methods 66 plasma samples of untreated HIV-infected pregnant women were collected in Dehong,Honghe,Lincang and Dali Prefectures in Yunnan from 2010 to 2012. HIV-1genotypes and the prevalent level of HIV-1 drug resistance transmission were analyzed. Results Based on pol sequences,CRF08_BC( 46. 97%) was the predominant subtype,followed by URF( 21. 21%),CRF07_BC( 10. 61%),CRF01_AE( 10. 61%),subtype C( 9. 09%) and subtype B( 1. 52%). Among the 66 samples,two strains contained Surveillance Drug Resistance Mutations( SDRM). The proportion of transmitted drug resistance was 3. 03%. One baby born to HIVpositive mother was diagnosed with HIV infection,the infection rate was 1. 52%. Conclusions CRF08_BC is the dominant subtype of circulating HIV-1 genotype in the pregnant women investigated,and HIV-1 drug resistance is still catalogued as a low prevalence level among untreated HIV-infected pregnant women in Yunnan Province. To prevent the increase of the prevalence of transmitted HIV-1 drug resistance,on the base of strengthening HIV prevention and control in the key population,the standard treatment and scientific management to AIDS patients should be improved,and the drug resistance surveillance should be performed periodically." @default.
- W2350198452 created "2016-06-24" @default.
- W2350198452 creator A5049138145 @default.
- W2350198452 date "2014-01-01" @default.
- W2350198452 modified "2023-09-23" @default.
- W2350198452 title "HIV-1genotype and its transmitted drug resistance among pregnant women in Yunnan Province" @default.
- W2350198452 hasPublicationYear "2014" @default.
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