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- W2350205179 abstract "The acute toxicity of curcin derived from seeds of Jatropha curcas to organs in mice was studied.Mice were intraperitoneally injected with curcin in solution at a concentration of(20,25,31,38.4,48 or 60)×10-3 g/kg.The LD50 by Bliss method was 37.709×10-3 g/kg,while (33.228～43.151)×10-3 g/kg at 95% average confident limit.Studies via pathological sectioning for the above-mentioned mice showed a.at a dose of 20×10-3 g/kg hardly any abnormal change in their organs;b.at a dose of(25～48)×10-3 g/kg,focal oedema and congestion in some organs such as liver,kidney and lung,with no vital organ heavily impaired;and c.at a dose of 60×10-3 g/kg,oedema and haemorrhage in liver,haemorrhage,congestion and focally exudative fibrin in lung,obvious congestion in pancreas,in some subjects,even fatty pancreas and/or diffuse hyperemia in kidney.These results provide information useful for application of curcin in immunotoxin preparation." @default.
- W2350205179 created "2016-06-24" @default.
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- W2350205179 date "2008-01-01" @default.
- W2350205179 modified "2023-09-23" @default.
- W2350205179 title "Studies on acute toxicity of Curcin from Jatropha curcas to organs in mice" @default.
- W2350205179 hasPublicationYear "2008" @default.
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