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- W2350205324 abstract "Objective: To explore the effect of Acanthopanax senticousus saponins (ASS) on cortical neuron damage induced by glutamate. Methods: Cortical neurons were removed form 13-15-day-old embryonic ICR mice fetuses aseptic-ally and primary cultivated in the L-15 medium. The model of damage induced by glutamate was established on cultured cortical neurons. The neuron viability was measured by MTT assay and release of LDH, NO contents were determined by Nitrate reductase assay and the rate of neuronal apoptosis was measured by flow cytometer system. The changes of morphology were observed by electron microscopy. Results:(1)Compared to the control group, Glutamate could decrease the cortical neuron survival dose-and-time-dependently, ASS could increase neuron survival. (2) Compared to the control group, the neuron apoptosis and the release of LDH and NO contents increased(P0. 01). ASS could decrease neuron apoptosis and LDH quantity, inhibit the NO contents. Conclusions: ASS plays a protective role in the cortical neuron damage induced by glutamate via inhibiting the release of NO and stabilizing cell membrane." @default.
- W2350205324 created "2016-06-24" @default.
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- W2350205324 date "2004-01-01" @default.
- W2350205324 modified "2023-09-23" @default.
- W2350205324 title "Protective Effect of Acanthopanax Senticousus Saponins on Glutamate-induced Cortical Neuron Damage" @default.
- W2350205324 hasPublicationYear "2004" @default.
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