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- W2350216881 abstract "Objective To investigate the effects of simvastatin on serum intercellular adhesion molecule-1(sICAM-1),p-selectin,and lipid levels in patients with acute cerebral infarction(ACI).Methods 110 cases with ACI were randomly divided into two therapy groups:(1)56 cases were given simvastatin combined with Aspirin;(2)54 cases were treated with Aspirin only.serum levels of sICAM-1,p-selectin and lipid were detected with in 72h in the onset of the disease and 3 months following the treatment.Meanwhile,the same were detected in the control group(50 healthy people).Results Within 72 h,the serum levels of sICAM-1,p-selectin,cholesterol and LDL were higher in patients with ACI than those in control group(both P0.05).Compared with that before treatment and Aspirin therapy group,the serum levels of sICAM-1,p-selectin,cholesterol and LDL were obviously decreased in Pravastatin combined with Aspirintherapy group 3 months after the treatment(both P0.05).Conclusion Simvastatin may benefit lowering the serum levels of sICAM-1 and p-selectin,modulating immunological function and restraining inflammation so that it can further stabilize atheromatous plaque.Therefore,Pravastatin combined with Aspirin can be a good approach to treating ACI." @default.
- W2350216881 created "2016-06-24" @default.
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- W2350216881 date "2009-01-01" @default.
- W2350216881 modified "2023-09-22" @default.
- W2350216881 title "Effects of simvastatin on serum sICAM-1 and p-selectin levels in patients with acute cerebral infarction" @default.
- W2350216881 hasPublicationYear "2009" @default.
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