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- W2350232411 abstract "Objective: To investigate Baishile capsule on behavior,neuronal apoptosis in hippocampus and the expression of B cell lymphome / leukemia-2( Bcl-2) and Bcl-2 associated x protein( Bax) in chronic depression model rats. Method: Rat chronic stress depression model was established by chronic and mild unpredictable stressors. The observationt of body weight,open-field test,preference for 1% sucrose solution were carried out. SD rats were randomly divided into control group,model group,fluoxetine hydrochloride group,and Baishile capsule( 2. 88,1. 44,0. 72 g·kg- 1) group,administered ig for 21 days. Neuronal apoptosis in the hippocampus of rats were assayed by TUNEL staining; the expression of Bcl-2 and Bax was observed by immunohistochemistry. Result: Compared with control group,the weight gain,horizontal and vertical activities,1% sucrose solution in the model group decreased significantly( P 0. 01),the proportion of apoptotic cells and apoptotic cell count were significantly increased in model group( P 0. 01),Bcl-2 protein expression decreased( P 0. 01),and Bax protein expression increased( P 0. 01). Baishile capsule high and middle dose group could significantly increase the body weight at 14,21 d( P 0. 01); and significantly increase the horizontal and vertical activities of score( P 0. 01 or P 0. 05),increase 1% sucrose solution( P 0. 01 or P 0. 05).Immunohistochemistry result showed that high dose group could increase the expression of Bcl-2( P 0. 05) and decrease the proportion of apoptotic cells and apoptotic cell count, and expression of Bax( P 0. 05).Conclusion: Baishile capsule could play a role of antidepressant by reducing apoptosis of hippocampal neurons." @default.
- W2350232411 created "2016-06-24" @default.
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- W2350232411 date "2013-01-01" @default.
- W2350232411 modified "2023-09-25" @default.
- W2350232411 title "Effect of Baishile Capsule on the Apoptosis of Hippocampal in Rat Chronic Depression Stress Model" @default.
- W2350232411 hasPublicationYear "2013" @default.
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